Impact of different age ranges on the benefits and harms of the breast cancer screening programme by the EU-TOPIA tool.
Eur J Public Health
; 34(4): 806-811, 2024 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-38578614
ABSTRACT
BACKGROUND:
The recommendation for the implementation of mammography screening in women aged 45-49 and 70-74 is conditional with moderate certainty of the evidence. The aim of this study is to simulate the long-term outcomes (2020-50) of using different age range scenarios in the breast cancer screening programme of the Valencia Region (Spain), considering different programme participation rates.METHODS:
Three age range scenarios (S) were simulated with the EU-TOPIA tool, considering a biennial screening interval S1, 45-69 years old (y); S2, 50-69 y and S3, 45-74 y. Simulations were performed for four participation rates A = current participation (72.7%), B = +5%, C = +10% and D = +20%. Considered benefits number (N°) of in situ and invasive breast cancers (BC) (screen vs. clinically detected), N° of BC deaths and % BC mortality reduction. Considered harms N° of false positives (FP) and % overdiagnosis.RESULTS:
The results showed that BC mortality decreased in all scenarios, being higher in S3A (32.2%) than S1A (30.6%) and S2A (27.9%). Harms decreased in S2A vs. S1A (N° FP 236 vs. 423, overdiagnosis 4.9% vs. 5.0%) but also benefits (BC mortality reduction 27.9% vs. 30.6%, N° screen-detected invasive BC 15/28 vs. 18/25). In S3A vs. S1A, an increase in benefits was observed (BC mortality reduction 32.2% vs. 30.6%), N° screen-detected in situ B 5/2 vs. 4/3), but also in harms (N° FP 460 vs. 423, overdiagnosis 5.8% vs. 5.0%). Similar trends were observed with increased participation.CONCLUSIONS:
As the age range increases, so does not only the reduction in BC mortality, but also the probability of FP and overdiagnosis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Mamografia
/
Detecção Precoce de Câncer
Limite:
Aged
/
Female
/
Humans
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Eur J Public Health
Assunto da revista:
EPIDEMIOLOGIA
/
SAUDE PUBLICA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Espanha