Learning, Fast and Slow: Single- and Many-Shot Learning in the Hippocampus.
Annu Rev Neurosci
; 47(1): 187-209, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38663090
ABSTRACT
The hippocampus is critical for memory and spatial navigation. The ability to map novel environments, as well as more abstract conceptual relationships, is fundamental to the cognitive flexibility that humans and other animals require to survive in a dynamic world. In this review, we survey recent advances in our understanding of how this flexibility is implemented anatomically and functionally by hippocampal circuitry, during both active exploration (online) and rest (offline). We discuss the advantages and limitations of spike timing-dependent plasticity and the more recently discovered behavioral timescale synaptic plasticity in supporting distinct learning modes in the hippocampus. Finally, we suggest complementary roles for these plasticity types in explaining many-shot and single-shot learning in the hippocampus and discuss how these rules could work together to support the learning of cognitive maps.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hipocampo
/
Aprendizagem
/
Plasticidade Neuronal
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Ann. rev. neurosci
/
Annu Rev Neurosci
/
Annual review of neuroscience
Ano de publicação:
2024
Tipo de documento:
Article