Fur-mediated regulation of hydrogen sulfide synthesis, stress response, and virulence in Edwardsiella piscicida.
Microbiol Res
; 284: 127735, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38678681
ABSTRACT
The production of endogenous hydrogen sulfide (H2S) is an important phenotype of bacteria. H2S plays an important role in bacterial resistance to ROS and antibiotics, which significantly contributes to bacterial pathogenicity. Edwardsiella piscicida, the Gram-negative pathogen causing fish edwardsiellosis, has been documented to produce hydrogen sulfide. In the study, we revealed that Ferric uptake regulator (Fur) controlled H2S synthesis by activating the expression of phsABC operon. Besides, Fur participated in the bacterial defense against ROS and cationic antimicrobial peptides and modulated T3SS expression. Furthermore, the disruption of fur exhibited a significant in vivo colonization defect. Collectively, our study demonstrated the regulation of Fur in H2S synthesis, stress response, and virulence, providing a new perspective for better understanding the pathogenesis of Edwardsiella.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Fisiológico
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Proteínas de Bactérias
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Regulação Bacteriana da Expressão Gênica
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Edwardsiella
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Infecções por Enterobacteriaceae
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Doenças dos Peixes
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Sulfeto de Hidrogênio
Limite:
Animals
Idioma:
En
Revista:
Microbiol Res
Assunto da revista:
MICROBIOLOGIA
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SAUDE AMBIENTAL
Ano de publicação:
2024
Tipo de documento:
Article