Smoking status and clinical outcome in idiopathic pulmonary fibrosis: a nationwide study.
Respir Res
; 25(1): 191, 2024 Apr 29.
Article
em En
| MEDLINE
| ID: mdl-38685071
ABSTRACT
BACKGROUND:
Smoking status has been linked to the development of idiopathic pulmonary fibrosis (IPF). However, the effect of smoking on the prognosis of patients with IPF is unclear. We aimed to investigate the association between smoking status and all-cause mortality or hospitalisation by using national health claims data.METHODS:
IPF cases were defined as people who visited medical institutions between January 2002 and December 2018 with IPF and rare incurable disease exempted calculation codes from the National Health Insurance Database. Total 10,182 patients with available data on smoking status were included in this study. Ever-smoking status was assigned to individuals with a history of smoking ≥ 6 pack-years. The multivariable Cox proportional hazard model was used to evaluate the association between smoking status and prognosis.RESULTS:
In the entire cohort, the mean age was 69.4 years, 73.9% were males, and 45.2% were ever smokers (current smokers 14.2%; former smokers 31.0%). Current smokers (hazard ratio [HR] 0.709; 95% confidence interval [CI] 0.643-0.782) and former smokers (HR 0.926; 95% CI 0.862-0.996) were independently associated with all-cause mortality compared with non-smokers. Current smokers (HR 0.884; 95% CI 0.827-0.945) and former smokers (HR 0.909; 95% CI 0.862-0.959) were also associated with a reduced risk of all-cause hospitalisation compared with non-smokers. A non-linear association between smoking amount and prognosis was found in a spline HR curve and showed increasing risk below 6 pack-years.CONCLUSION:
Ever-smoking status may be associated with favourable clinical outcomes in patients with IPF.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fumar
/
Fibrose Pulmonar Idiopática
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Respir Res
Ano de publicação:
2024
Tipo de documento:
Article