Identifying the potential therapeutic effects of miR6516 on muscle disuse atrophy.
Mol Med Rep
; 30(1)2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38757344
ABSTRACT
Muscle atrophy is a debilitating condition with various causes; while aging is one of these causes, reduced engagement in routine musclestrengthening activities also markedly contributes to muscle loss. Although extensive research has been conducted on microRNAs (miRNAs/miRs) and their associations with muscle atrophy, the roles played by miRNA precursors remain underexplored. The present study detected the upregulation of the miR206 precursor in cellfree (cf)RNA from the plasma of patients at risk of sarcopenia, and in cfRNAs from the muscles of mice subjected to muscle atrophy. Additionally, a decline in the levels of the miR6516 precursor was observed in mice with muscle atrophy. The administration of mimicmiR6516 to mice immobilized due to injury inhibited muscle atrophy by targeting and inhibiting cyclindependent kinase inhibitor 1b (Cdkn1b). Based on these results, the miR206 precursor appears to be a potential biomarker of muscle atrophy, whereas miR6516 shows promise as a therapeutic target to alleviate muscle deterioration in patients with muscle disuse and atrophy.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Atrofia Muscular
/
Transtornos Musculares Atróficos
/
MicroRNAs
Limite:
Adult
/
Aged
/
Animals
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Mol Med Rep
Ano de publicação:
2024
Tipo de documento:
Article