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The 8th AJCC classification is inferior to a new neck stage based on intraparotid lymph node in parotid gland cancer.
Han, Xiaoxue; Yang, Changyu; Tan, Xuexin; Li, Yuexiao.
Afiliação
  • Han X; Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, No.117 Nanjing North Street, Heping District, Shenyang, 110002, Liaoning, P.R. China.
  • Yang C; Department of Stomatology, The Fourth Affiliated Hospital of China Medical University, Shenyang, P.R. China.
  • Tan X; Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, No.117 Nanjing North Street, Heping District, Shenyang, 110002, Liaoning, P.R. China.
  • Li Y; Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, No.117 Nanjing North Street, Heping District, Shenyang, 110002, Liaoning, P.R. China. liyuexiaocmu@hotmail.com.
BMC Oral Health ; 24(1): 590, 2024 May 21.
Article em En | MEDLINE | ID: mdl-38773438
ABSTRACT

BACKGROUND:

Lymph node (LN) status is an important prognostic factor for parotid gland cancer (PGC). This study aimed to analyze the impact of extranodal extension (ENE) of intraparotid LN and LN metastasis burden on survival in PGC.

METHODS:

Patients with surgically treated PGC and at least one metastatic cervical LN were retrospectively enrolled. Primary outcome variables were distant metastasis-free survival (DMFS), disease-specific survival (DSS), and overall survival (OS). The impact of ENE and LN metastasis burden was assessed using the Cox model.

RESULTS:

A total of 292 patients were included. ENE in cervical or intraparotid LN was not associated with DMFS, DSS, or OS. Intraparotid LN metastasis had a significant impact on prognosis, and the presence of only one metastatic intraparotid LN offered an approximately 1.5-fold risk of distant metastasis. Prognostic models based on the number of positive LNs (1 vs. 2-3 vs. 4+) were superior to the AJCC N stage in terms of DMFS, DSS, and OS.

CONCLUSIONS:

ENE of cervical or intraparotid LN has a limited effect on the prognosis of PGC, and the number of positive LNs is better than the AJCC N stage in LN status evaluation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Parotídeas / Linfonodos / Metástase Linfática / Estadiamento de Neoplasias Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Oral Health Assunto da revista: ODONTOLOGIA Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Parotídeas / Linfonodos / Metástase Linfática / Estadiamento de Neoplasias Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Oral Health Assunto da revista: ODONTOLOGIA Ano de publicação: 2024 Tipo de documento: Article