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Stroke and frailty index: a two-sample Mendelian randomisation study.
Wei, Jiangnan; Wang, Jiaxian; Chen, Jiayin; Yang, Kezhou; Liu, Ning.
Afiliação
  • Wei J; Department of Nursing, Zhuhai Campus of Zunyi Medical University, No. 368 Jinwan Road, Zhuhai, Guangdong, China.
  • Wang J; Department of Nursing, Zhuhai Campus of Zunyi Medical University, No. 368 Jinwan Road, Zhuhai, Guangdong, China.
  • Chen J; Department of Nursing, Zhuhai Campus of Zunyi Medical University, No. 368 Jinwan Road, Zhuhai, Guangdong, China.
  • Yang K; Department of Nursing, Zhuhai Campus of Zunyi Medical University, No. 368 Jinwan Road, Zhuhai, Guangdong, China.
  • Liu N; Department of Fundamentals, Department of Basic Teaching and Research in General Medicine, Zunyi Medical University Zhuhai Campus, Zhuhai, Guangdong, China. ln761066906@163.com.
Aging Clin Exp Res ; 36(1): 114, 2024 May 22.
Article em En | MEDLINE | ID: mdl-38775917
ABSTRACT

INTRODUCTION:

Previous observational studies have found an increased risk of frailty in patients with stroke. However, evidence of a causal relationship between stroke and frailty is scarce. The aim of this study was to investigate the potential causal relationship between stroke and frailty index (FI).

METHODS:

Pooled data on stroke and debility were obtained from genome-wide association studies (GWAS).The MEGASTROKE Consortium provided data on stroke (N = 40,585), ischemic stroke (IS,N = 34,217), large-vessel atherosclerotic stroke (LAS,N = 4373), and cardioembolic stroke (CES,N = 7 193).Summary statistics for the FI were obtained from the most recent GWAS meta-analysis of UK BioBank participants and Swedish TwinGene participants of European ancestry (N = 175,226).Two-sample Mendelian randomization (MR) analyses were performed by inverse variance weighting (IVW), weighted median, MR-Egger regression, Simple mode, and Weighted mode, and heterogeneity and horizontal multiplicity of results were assessed using Cochran's Q test and MR-Egger regression intercept term test.

RESULTS:

The results of the current MR study showed a significant correlation between stroke gene prediction and FI (odds ratio 1.104, 95% confidence interval 1.064 - 1.144, P < 0.001). In terms of stroke subtypes, IS (odds ratio 1.081, 95% confidence interval 1.044 - 1.120, P < 0.001) and LAS (odds ratio 1.037, 95% confidence interval 1.012 - 1.062, P = 0.005). There was no causal relationship between gene-predicted CES and FI. Horizontal multidimensionality was not found in the intercept test for MR Egger regression (P > 0.05), nor in the heterogeneity test (P > 0.05).

CONCLUSIONS:

This study provides evidence for a causal relationship between stroke and FI and offers new insights into the genetic study of FI.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acidente Vascular Cerebral / Estudo de Associação Genômica Ampla / Análise da Randomização Mendeliana / Fragilidade Limite: Aged / Female / Humans / Male Idioma: En Revista: Aging Clin Exp Res Assunto da revista: GERIATRIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acidente Vascular Cerebral / Estudo de Associação Genômica Ampla / Análise da Randomização Mendeliana / Fragilidade Limite: Aged / Female / Humans / Male Idioma: En Revista: Aging Clin Exp Res Assunto da revista: GERIATRIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China