Selenium-catalyzed allylic C-H phosphoramidation of alkenes.

Huang, Chengjie; Yang, Tao; Jia, Jingyang; Fu, Songsen; Hong, Bang; Wu, Fan; Ni, Feng

Huang, Chengjie; Yang, Tao; Jia, Jingyang; Fu, Songsen; Hong, Bang; Wu, Fan; Ni, Feng.

Afiliação

Huang C; Institute of Drug Discovery Technology and Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo, Zhejiang 315211, China. wufan@nbu.edu.cn.
Yang T; Institute of Drug Discovery Technology and Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo, Zhejiang 315211, China. wufan@nbu.edu.cn.
Jia J; Institute of Drug Discovery Technology and Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo, Zhejiang 315211, China. wufan@nbu.edu.cn.
Fu S; Institute of Drug Discovery Technology and Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo, Zhejiang 315211, China. wufan@nbu.edu.cn.
Hong B; LeadArt Technologies Ltd, Ningbo, 315211, China.
Wu F; Institute of Drug Discovery Technology and Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo, Zhejiang 315211, China. wufan@nbu.edu.cn.
Ni F; Institute of Drug Discovery Technology and Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo, Zhejiang 315211, China. wufan@nbu.edu.cn.

Org Biomol Chem ; 22(24): 4882-4887, 2024 Jun 19.

Article em En | MEDLINE | ID: mdl-38809155

ABSTRACT

ABSTRACT

We report herein a synthesis of allylic phosphoramidates from alkenes by selenium-catalyzed allylic C-H derivatization. This method features mild conditions, broad substrate scope, and high functional group tolerance, enabling late-stage modification of a number of complex substrates. In addition, this protocol was applied to modify caryophyllene and produced a photoaffinity probe capable of proteomic target labeling in live HeLa cells.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

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