Your browser doesn't support javascript.
loading
Preventive Effects of Dental Pulp Stem Cell-conditioned Media on Anti-RANKL Antibody-Related Osteonecrosis of the Jaw.
Kaminogo, Kento; Yamaguchi, Satoshi; Chen, Hui; Yagita, Hideo; Toyama, Naoto; Urata, Yusuke; Hibi, Hideharu.
Afiliação
  • Kaminogo K; Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.
  • Yamaguchi S; Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan. syamaguchi@med.nagoya-u.ac.jp.
  • Chen H; Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.
  • Yagita H; Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan.
  • Toyama N; Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.
  • Urata Y; Department of Oral and Maxillofacial Surgery, Iwata City Hospital, Iwata, Japan.
  • Hibi H; Department of Oral and Maxillofacial Surgery, Nagoya University Hospital, Nagoya, Japan.
Calcif Tissue Int ; 115(2): 185-195, 2024 Aug.
Article em En | MEDLINE | ID: mdl-38809297
ABSTRACT
Medication-related osteonecrosis of the jaw is a serious disease occurring in patients with cancer and osteoporosis, who are undergoing treatment with antiresorptive agents (ARAs) such as bisphosphonate (BP) or denosumab, an antibody targeting receptor activator of NF-κB ligand. Recently, stem cell-based therapy has been shown to be effective in preventing the development of bisphosphonate-related osteonecrosis of the jaw. However, studies on denosumab-related osteonecrosis of the jaw (DRONJ) remain limited. Here, the efficacy of treatment with dental pulp stem cell conditioned media (DPSC-CM) in preventing DRONJ in a murine model was evaluated. Local administration of DPSC-CM into the extraction socket of a mouse with DRONJ decreased the number of empty osteocyte lacunae and the prevalence of ONJ. In tissues surrounding the extraction sockets in the DPSC-CM-treated group, the expression of inflammatory cytokines was attenuated and that of osteogenesis-related molecules was enhanced compared to that in the control group. Further, the expression of Wnt signaling molecules, which had been suppressed, was improved. These findings collectively suggest that DPSC-CM prevents ONJ development in a murine DRONJ model.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco / Polpa Dentária / Ligante RANK / Osteonecrose da Arcada Osseodentária Associada a Difosfonatos / Denosumab Limite: Animals / Humans / Male Idioma: En Revista: Calcif Tissue Int Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco / Polpa Dentária / Ligante RANK / Osteonecrose da Arcada Osseodentária Associada a Difosfonatos / Denosumab Limite: Animals / Humans / Male Idioma: En Revista: Calcif Tissue Int Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão