Little ones can do big things: Small molecule inhibitors target PTPN2/PTPN1 for tumor immunotherapy.
MedComm (2020)
; 5(6): e567, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38817652
ABSTRACT
AC484 was developed by designing compounds based on the PTPN2 protein structure. AC484 enhances antitumor immunity through multiple mechanisms increasing tumor sensitivity to IFN-γ, improving T-cell functions, stimulating tumor microenvironment inflammation, expanding TCR diversity, and preventing T-cell exhaustion. Interestingly, the efficacy of AC484 was also mediated by CD8+ and NK cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
MedComm (2020)
Ano de publicação:
2024
Tipo de documento:
Article