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The Impact of the COVID-19 Pandemic on Incidence and Short-Term Survival for Common Solid Tumours in the United Kingdom: A Cohort Analysis.
Barclay, Nicola L; Burkard, Theresa; Burn, Edward; Delmestri, Antonella; Miquel Dominguez, Andrea; Golozar, Asieh; Guarner-Argente, Carlos; Avilés-Jurado, Francesc Xavier; Man, Wai Yi; Roselló Serrano, Àlvar; Rosen, Andreas Weinberger; Tan, Eng Hooi; Tietzova, Ilona; Prieto Alhambra, Daniel; Newby, Danielle.
Afiliação
  • Barclay NL; Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
  • Burkard T; Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
  • Burn E; Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
  • Delmestri A; Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
  • Miquel Dominguez A; Otorrinolaringology department, Hospital Joan XXIII de Tarragona, Tarragona, Spain.
  • Golozar A; Odysseus Data Services, Cambridge, MA, USA.
  • Guarner-Argente C; Gastroenterology Department, Hospital de la Santa Creu I Sant Pau, Universitat Autònoma de Barcelona, Sant Quintí, Barcelona, Spain.
  • Avilés-Jurado FX; Head Neck Tumors Unit, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.
  • Man WY; Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
  • Roselló Serrano À; Institut Català d'Oncologia, Hospital Universitari Dr Josep Trueta, Girona, Spain.
  • Rosen AW; Centre for Surgical Science, Department of Surgery, Zealand University Hospital, Koege, Denmark.
  • Tan EH; Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
  • Tietzova I; First Department of Tuberculosis and Respiratory Diseases, First Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Prieto Alhambra D; Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
  • Newby D; Department of Medical Informatics, Erasmus University Medical Centre, Rotterdam, the Netherlands.
Clin Epidemiol ; 16: 417-429, 2024.
Article em En | MEDLINE | ID: mdl-38882578
ABSTRACT

Purpose:

The COVID-19 pandemic profoundly affected healthcare systems and patients. There is a need to comprehend the collateral effects of the pandemic on non-communicable diseases. We examined the impact of the pandemic on short-term survival for common solid tumours, including breast, colorectal, head and neck, liver, lung, oesophageal, pancreatic, prostate, and stomach cancer in the UK.

Methods:

This was a population-based cohort study of electronic health records from the UK primary care Clinical Practice Research Datalink GOLD database. In sum, 12,259,744 eligible patients aged ≥18 years with ≥1 year's history identified from January 2000 to December 2022 were included. We estimated age-standardised incidence and short-term (one- and two-year) survival for several common cancers from 2000 to 2019 (in five-year strata) and compared these to 2020-2022 using the Kaplan-Meier method.

Results:

Incidence decreased for most cancers in 2020 and recovered to different extents in 2021-2022. Short-term survival improved for most cancers between 2000 and 2019, but then declined, albeit minimally, for those diagnosed in 2020-2022. This was most pronounced for colorectal cancer, with one-year survival falling from 78.8% (95% CI 78%-79.6%) in 2015-2019 to 77% (95% CI 75.6-78.3%) for those diagnosed in 2020-2022.

Conclusion:

Short-term survival for many cancers was impacted, albeit minimally, by the pandemic in the UK, with reductions in survivorship from colorectal cancer equivalent to returning to the mortality seen in the first decade of the 2000s. While data on longer-term survival are needed to fully comprehend the impact of COVID-19 on cancer care, our findings illustrate the need for an urgent and substantial commitment from the UK National Health Service to address the existing backlog in cancer screening and diagnostic procedures to improve cancer care and mortality.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Clin Epidemiol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Clin Epidemiol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Reino Unido