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Infrared Spectroscopy in Gynecological Oncology: A Comprehensive Review of Diagnostic Potentials and Challenges.
Delrue, Charlotte; De Bruyne, Sander; Oyaert, Matthijs; Delanghe, Joris R; Moresco, Rafael Noal; Speeckaert, Reinhart; Speeckaert, Marijn M.
Afiliação
  • Delrue C; Department of Nephrology, Ghent University Hospital, 9000 Ghent, Belgium.
  • De Bruyne S; Department of Clinical Biology, Ghent University Hospital, 9000 Ghent, Belgium.
  • Oyaert M; Department of Clinical Biology, Ghent University Hospital, 9000 Ghent, Belgium.
  • Delanghe JR; Department of Diagnostic Sciences, Ghent University Hospital, C. Heymanslaan 10, 9000 Ghent, Belgium.
  • Moresco RN; Graduate Program in Pharmaceutical Sciences, Center of Health Sciences, Federal University of Santa Maria, Santa Maria 72500-000, Brazil.
  • Speeckaert R; Department of Dermatology, Ghent University Hospital, 9000 Ghent, Belgium.
  • Speeckaert MM; Department of Nephrology, Ghent University Hospital, 9000 Ghent, Belgium.
Int J Mol Sci ; 25(11)2024 May 30.
Article em En | MEDLINE | ID: mdl-38892184
ABSTRACT
The early detection of gynecological cancers, which is critical for improving patient survival rates, is challenging because of the vague early symptoms and the diagnostic limitations of current approaches. This comprehensive review delves into the game-changing potential of infrared (IR) spectroscopy, a noninvasive technology used to transform the landscape of cancer diagnosis in gynecology. By collecting the distinctive vibrational frequencies of chemical bonds inside tissue samples, Fourier-transform infrared (FTIR) spectroscopy provides a 'molecular fingerprint' that outperforms existing diagnostic approaches. We highlight significant advances in this field, particularly the identification of discrete biomarker bands in the mid- and near-IR spectra. Proteins, lipids, carbohydrates, and nucleic acids exhibited different absorption patterns. These spectral signatures not only serve to distinguish between malignant and benign diseases, but also provide additional information regarding the cellular changes associated with cancer. To underscore the practical consequences of these findings, we examined studies in which IR spectroscopy demonstrated exceptional diagnostic accuracy. This review supports the use of IR spectroscopy in normal clinical practice, emphasizing its capacity to detect and comprehend the intricate molecular underpinnings of gynecological cancers.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias dos Genitais Femininos Limite: Female / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Bélgica

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias dos Genitais Femininos Limite: Female / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Bélgica