Molecular regulators of defective placental and cardiovascular development in fetal growth restriction.
Clin Sci (Lond)
; 138(13): 761-775, 2024 Jul 03.
Article
em En
| MEDLINE
| ID: mdl-38904187
ABSTRACT
Placental insufficiency is one of the major causes of fetal growth restriction (FGR), a significant pregnancy disorder in which the fetus fails to achieve its full growth potential in utero. As well as the acute consequences of being born too small, affected offspring are at increased risk of cardiovascular disease, diabetes and other chronic diseases in later life. The placenta and heart develop concurrently, therefore placental maldevelopment and function in FGR may have profound effect on the growth and differentiation of many organ systems, including the heart. Hence, understanding the key molecular players that are synergistically linked in the development of the placenta and heart is critical. This review highlights the key growth factors, angiogenic molecules and transcription factors that are common causes of defective placental and cardiovascular development.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Retardo do Crescimento Fetal
Limite:
Animals
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Clin Sci (Lond)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Nova Zelândia