Age-related differences in retinal function and structure in C57BL/6J and Thy1-YFPh mice.
Neurobiol Aging
; 141: 171-181, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38964014
ABSTRACT
Age-related neuronal adaptations are known to help maintain function. This study aims to examine gross age-related in vivo retinal functional adaptations (using electroretinography) in young and middle aged C57BL/6J and Thy1-YFPh mice and to relate this to in vivo retinal structure (using optical coherence tomography). Electroretinography responses were generally larger in Thy1-YFPh mice than in C57BL/6J mice, with similar in vivo retinal layer thicknesses except for longer inner/outer photoreceptor segment in Thy1-YFPh mice. Relative to 3-month-old mice, 12-month-old mice showed reduced photoreceptor (C57BL/6J 84.0±2.5â¯%; Thy1-YFPh 80.2±5.2â¯%) and bipolar cell (C57BL/6J 75.6±2.3â¯%; Thy1-YFPh 68.1±5.5â¯%) function. There was relative preservation of ganglion cell function (C57BL/6J 79.7±3.7â¯%; Thy1-YFPh 91.7±5.0â¯%) with age, which was associated with increased b-wave (bipolar cell) sensitivities to light. Ganglion cell function was correlated with both b-wave amplitude and sensitivity. This study shows that there are normal age-related adaptations to preserve functional output. Different mouse strains may have varied age-related adaptation capacity and should be taken into consideration when examining age-related susceptibility to injury.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retina
/
Envelhecimento
/
Eletrorretinografia
Limite:
Animals
Idioma:
En
Revista:
Neurobiol Aging
Ano de publicação:
2024
Tipo de documento:
Article