Cytotoxic Activity of Distinct Families of Phosphonic Acid Derivatives - A Chemocentric Approach to Assess Their Molecular Action.
ChemMedChem
; : e202400370, 2024 Jul 04.
Article
em En
| MEDLINE
| ID: mdl-38965788
ABSTRACT
Phosphorus containing small molecules (particularly α-aminophosphonates, α-hydroxyphosphonates and bisphosphonates) represent a unique chemical space among the biologically active compounds. We selected 35 diverse compounds that showed remarkable cytotoxicity effects on various cancer cell lines. However, the exact mechanism of action often requires further investigations, inâ
vitro or inâ
silico target identification even though many target-based activity data were gathered for the above cluster of compounds. In our conceptual account, we offer a systematic inâ
silico analysis between the cytotoxicity, cell lines, their (over)expressed protein targets associated with malignant diseases, and the activity data on protein targets already reported for those compounds in the hope that we gain better understanding and explanation, what is behind their cytotoxic behavior.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
ChemMedChem
Assunto da revista:
FARMACOLOGIA
/
QUIMICA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Hungria