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Radiomics-based analysis of dynamic contrast-enhanced magnetic resonance image: A prediction nomogram for lymphovascular invasion in breast cancer.
Yang, Xiuqi; Wang, Xuefei; Zuo, Zhichao; Zeng, Weihua; Liu, Haibo; Zhou, Lu; Wen, Yizhou; Long, Chuang; Tan, Siying; Li, Xiong; Zeng, Ying.
Afiliação
  • Yang X; Department of Radiology, Xiangtan Central Hospital, No. 120, Heping Road, Yuhu District, Xiangtan, Hunan 411000, China.
  • Wang X; Breast Surgery Department, Chinese Academy of Medical Sciences and Peking Union Medical College, Peking Union Medical College and Hospital, Beijing 100000, China.
  • Zuo Z; The School of Mathematics and Computational Science, Xiangtan University, Xiangtan, Hunan 411105, China.
  • Zeng W; Department of Radiology, Xiangtan Central Hospital, No. 120, Heping Road, Yuhu District, Xiangtan, Hunan 411000, China.
  • Liu H; Department of Radiology, Xiangtan Central Hospital, No. 120, Heping Road, Yuhu District, Xiangtan, Hunan 411000, China.
  • Zhou L; Department of Radiology, Xiangtan Central Hospital, No. 120, Heping Road, Yuhu District, Xiangtan, Hunan 411000, China.
  • Wen Y; Department of Radiology, Xiangtan Central Hospital, No. 120, Heping Road, Yuhu District, Xiangtan, Hunan 411000, China.
  • Long C; Department of Radiology, Xiangtan Central Hospital, No. 120, Heping Road, Yuhu District, Xiangtan, Hunan 411000, China.
  • Tan S; Department of Radiology, Xiangtan Central Hospital, No. 120, Heping Road, Yuhu District, Xiangtan, Hunan 411000, China.
  • Li X; Department of Radiology, Xiangtan Central Hospital, No. 120, Heping Road, Yuhu District, Xiangtan, Hunan 411000, China. Electronic address: lxccxshbm@126.com.
  • Zeng Y; Department of Radiology, Xiangtan Central Hospital, No. 120, Heping Road, Yuhu District, Xiangtan, Hunan 411000, China. Electronic address: zy6645295@163.com.
Magn Reson Imaging ; 112: 89-99, 2024 Oct.
Article em En | MEDLINE | ID: mdl-38971267
ABSTRACT

OBJECTIVE:

To develop and validate a nomogram for quantitively predicting lymphovascular invasion (LVI) of breast cancer (BC) based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) radiomics and morphological features.

METHODS:

We retrospectively divided 238 patients with BC into training and validation cohorts. Radiomic features from DCE-MRI were subdivided into A1 and A2, representing the first and second post-contrast images respectively. We utilized the minimal redundancy maximal relevance filter to extract radiomic features, then we employed the least absolute shrinkage and selection operator regression to screen these features and calculate individualized radiomics score (Rad score). Through the application of multivariate logistic regression, we built a prediction nomogram that integrated DCE-MRI radiomics and MR morphological features (MR-MF). The diagnostic capabilities were evaluated by comparing C-indices and calibration curves.

RESULTS:

The diagnostic efficiency of the A1/A2 radiomics model surpassed that of the A1 and A2 alone. Furthermore, we incorporated the MR-MF (diffusion-weighted imaging rim sign, peritumoral edema) and optimized Radiomics into a hybrid nomogram. The C-indices for the training and validation cohorts were 0.868 (95% CI 0.839-0.898) and 0.847 (95% CI 0.787-0.907), respectively, indicating a good level of discrimination. Moreover, the calibration plots demonstrated excellent agreement in the training and validation cohorts, confirming the effectiveness of the calibration.

CONCLUSION:

This nomogram combined MR-MF and A1/A2 Radiomics has the potential to preoperatively predict LVI in patients with BC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Imageamento por Ressonância Magnética / Meios de Contraste / Nomogramas / Radiômica / Invasividade Neoplásica Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Magn Reson Imaging Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Imageamento por Ressonância Magnética / Meios de Contraste / Nomogramas / Radiômica / Invasividade Neoplásica Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Magn Reson Imaging Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China