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The Diagnostic and Prognostic Value of the Combination of Tumor M2-Pyruvate Kinase, Carcinoembryonic Antigen, and Cytokeratin 19 Fragment in Non-Small Cell Lung Cancer.
Li, Li; Xu, Yihan; Wang, Yuchao; Zhang, Qian; Wang, Yan; Xu, Chunhua.
Afiliação
  • Li L; Department of Respiratory Medicine, Affiliated to Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
  • Xu Y; Department of Respiratory Medicine, Affiliated to Nanjing Chest Hospital, Southeast University, Nanjing, Jiangsu, China.
  • Wang Y; Nanjing Ninghai High School, Nanjing, Jiangsu, China.
  • Zhang Q; Department of Respiratory Medicine, Affiliated to Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
  • Wang Y; Department of Respiratory Medicine, Affiliated to Nanjing Chest Hospital, Southeast University, Nanjing, Jiangsu, China.
  • Xu C; Department of Respiratory Medicine, Affiliated to Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Technol Cancer Res Treat ; 23: 15330338241265983, 2024.
Article em En | MEDLINE | ID: mdl-39043046
ABSTRACT

Objective:

Finding biomarkers related to non-small cell lung cancer (NSCLC) is helpful for the diagnosis and precise treatment of lung cancer. The relationship between serum tumor M2-pyruvate kinase (TuM2-PK), carcinoembryonic antigen (CEA), and cytokeratin 19 fragment (CYFRA21-1) and NSCLC was analyzed.

Methods:

The serum levels of TuM2-PK, CEA, and CYFRA21-1 in 184 patients with the NSCLC group, 60 patients with the benign lung disease (BLD) group, and 90 healthy controls (HC) group were detected. The levels of TuM2-PK were measured by using an enzyme-linked immunosorbent assay. The detection methods of CEA and CYFRA21-1 were electrochemiluminescence. The receiver operating characteristic (ROC) curve was drawn to evaluate the diagnostic value of TuM2-PK, CEA, and CYFRA21-1 on NSCLC. The Kaplan-Meier survival curve was drawn to evaluate the survival status in NSCLC patients with different serum levels of TuM2-PK, CEA, and CYFRA21-1.

Results:

Serum levels of TuM2-PK, CEA, and CYFRA21-1 in the NSCLC group were significantly higher than those in the BLD group and the HC group (P < .01). Serum levels of TuM2-PK, CEA, and CYFRA21-1 in NSCLC patients were associated with the tumor lymph node metastasis stage (P < .05), lymph node metastasis (P < .05), and distant metastasis (P < .05). The ROC curve showed that the area under the curve of serum levels of TuM2-PK, CEA, and CYFRA21-1 was 0.814, 0.638, and 0.719, respectively, and that the combination of the above 3 was 0.918. The Kaplan-Meier survival curve showed that the 1-, 3- and 5-year survival rate in NSCLC patients with positive TuM2-PK, CEA, and CYFRA21-1 was significantly lower than that in NSCLC patients with negative TuM2-PK, CEA, and CYFRA21-1, respectively (P < .05).

Conclusions:

Serum TuM2-PK, CEA, and CYFRA21-1 levels have high clinical values in the diagnosis of NSCLC, and can effectively judge the prognosis of patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piruvato Quinase / Antígeno Carcinoembrionário / Biomarcadores Tumorais / Curva ROC / Carcinoma Pulmonar de Células não Pequenas / Queratina-19 / Neoplasias Pulmonares / Antígenos de Neoplasias Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Technol Cancer Res Treat Assunto da revista: NEOPLASIAS / TERAPEUTICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piruvato Quinase / Antígeno Carcinoembrionário / Biomarcadores Tumorais / Curva ROC / Carcinoma Pulmonar de Células não Pequenas / Queratina-19 / Neoplasias Pulmonares / Antígenos de Neoplasias Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Technol Cancer Res Treat Assunto da revista: NEOPLASIAS / TERAPEUTICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China