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Neuro-Ophthalmic Dengue Infection: A Case Report with a Multiple Body Site Sampling Strategy and Review of Laboratory Data.
Butel-Simoes, Grace I; Bajaj, Nupur; Asad, Sultan; Moselen, Jean; Orlando, Nicole; Steinig, Eike; Tran, Thomas; Druce, Julian; Caly, Leon; Bishop, Emma; Harangozo, Chanad; Lim, Chuan Kok.
Afiliação
  • Butel-Simoes GI; Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • Bajaj N; Department of Infectious Diseases, Peninsula Health, Melbourne, VIC 3199, Australia.
  • Asad S; Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • Moselen J; Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • Orlando N; Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • Steinig E; Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • Tran T; Department of Infectious Diseases, Doherty Institute of Infection and Immunity, The University of Melbourne, Melbourne, VIC 3000, Australia.
  • Druce J; Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • Caly L; Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • Bishop E; Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.
  • Harangozo C; Department of Infectious Diseases, Peninsula Health, Melbourne, VIC 3199, Australia.
  • Lim CK; Department of Infectious Diseases, Peninsula Health, Melbourne, VIC 3199, Australia.
Viruses ; 16(7)2024 Jun 21.
Article em En | MEDLINE | ID: mdl-39066161
ABSTRACT
Dengue neurological disease is an uncommon yet severe complication of dengue infection. It can manifest as encephalitis, encephalopathy, neuro-ophthalmic complications, or neuromuscular disorders. Severe infection can result in viral shedding across multiple body sites. We describe a case of severe neuro-ophthalmic dengue infection in an otherwise healthy returned traveller, presenting with prolonged multiple-body-site viral detections by PCR. The dengue virus (DENV) dynamics and serological response support a direct DENV neuropathogenicity. A retrospective review of the laboratory data at the Victorian Infectious Diseases Reference Laboratory (VIDRL) suggests that blood is the most frequent sample type with DENV detection (92% of all DENV-positive samples). Genotype variation is seen across different sample types. The similarity of CSF and nasopharyngeal DENV subtypes (genotype 1 and 3) suggests a possible correlation between nasopharyngeal replication and neurological complications. The case presented highlights the direct neuropathogenicity of DENV early in the course of infection, and a potential correlation between nasopharyngeal replication and neurological disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dengue / Vírus da Dengue Limite: Adult / Humans / Male Idioma: En Revista: Viruses Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Austrália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dengue / Vírus da Dengue Limite: Adult / Humans / Male Idioma: En Revista: Viruses Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Austrália