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Adolescent exposure to bisphenol-a antagonizes androgen regulation of social behavior in male mice.
Zhong, Xiaoyu; Li, Jisui; Xu, Xiaohong.
Afiliação
  • Zhong X; Life Science College, Key laboratory of Wildlife Biotechnology and Conservation and Utilization of Zhejiang Province, Zhejiang Normal University, PR China.
  • Li J; Life Science College, Key laboratory of Wildlife Biotechnology and Conservation and Utilization of Zhejiang Province, Zhejiang Normal University, PR China.
  • Xu X; Life Science College, Key laboratory of Wildlife Biotechnology and Conservation and Utilization of Zhejiang Province, Zhejiang Normal University, PR China. Electronic address: xuxh63@zjnu.cn.
Neurotoxicol Teratol ; 105: 107374, 2024.
Article em En | MEDLINE | ID: mdl-39097242
ABSTRACT
Social behavior is sexually dimorphic, which is regulated by gonadal hormones in the brain. Our recent study found that exposure to low doses of bisphenol-A (BPA) during adolescence, permanently alters social behavior in adult male mice, but the underlying mechanisms remain unclear. Using adolescent gonadectomy (GDX) male mice with testosterone propionate (TP, 0.5 mg/kg) supplement (TP-GDX), this study showed that BPA antagonized promoting effects of TP on social interaction, sexual behavior, and aggression in GDX mice. BPA eliminated the reversal effects of TP on GDX-induced decrease in the number of immunoreactive to arginine vasopressin (AVP-ir) neurons in the medial amygdala (MeA) and the levels of AVP receptor 1a (V1aR) in the MeA and the nucleus accumbens (NAc). In addition, BPA removed down-regulation in the levels of dopamine (DA) transporter (DAT) and DA receptor 1 (DR1) in the NAc of TP-GDX mice. BPA exposure reduced testosterone (T) levels in the brain and serum and the expression of androgen receptor (AR) protein in the amygdala and striatum of sham-operated and TP-GDX males. These results suggest that adolescent exposure to BPA inhibits regulation of androgen in AVP and DA systems of the brain regions associated with social behavior, and thus alters social behaviors of adult male mice.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenóis / Comportamento Social / Compostos Benzidrílicos / Receptores Androgênicos Limite: Animals Idioma: En Revista: Neurotoxicol Teratol Assunto da revista: NEUROLOGIA / TOXICOLOGIA Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenóis / Comportamento Social / Compostos Benzidrílicos / Receptores Androgênicos Limite: Animals Idioma: En Revista: Neurotoxicol Teratol Assunto da revista: NEUROLOGIA / TOXICOLOGIA Ano de publicação: 2024 Tipo de documento: Article