Serum uric acid, body mass index, and cardiovascular diseases: A multiple two-step Mendelian randomization study.
Nutr Metab Cardiovasc Dis
; 34(10): 2386-2394, 2024 Oct.
Article
em En
| MEDLINE
| ID: mdl-39097442
ABSTRACT
BACKGROUND AND AIMS:
A number of health issues, including high serum uric acid (SUA) and cardiovascular disease (CVD), have been linked to obesity based on observational evidence, though it's currently unclear how these issues are causally related. In order to determine whether obesity mediates this association, we set out to investigate the causal relationship between SUA, obesity, and CVD. METHODS ANDRESULTS:
From publicly available genome-wide association studies, we acquired instrumental variables that had a strong correlation to SUA and body mass index (BMI). We employed multiple two-step Mendelian randomization (MR) analyses, using genetic and clinical data from various publicly available biological databases. The mediating role of BMI was examined through mediation analysis. SUA was genetically correlated with BMI [OR = 1.080, 95% CI 1.024-1.139, P = 0.005]. There was a positive causal effect of SUA on AF [OR = 0.892, 95% CI 0.804-0.990, P = 0.032], CAD [OR = 0.942, 95% CI 0.890-0.997, P = 0.037], and EHT [OR = 1.080, 95% CI 1.024-1.139, P = 0.005]. Among them, BMI mediated the effects of SUA on AF (42.2%; 95% CI, 35.3%-51.9%), CAD (76.3%; 95% CI, 63.4%-92.0%), and EHT (10.0%; 95% CI, 0%-20.0%).CONCLUSION:
Our research revealed a causal relationship between high SUA exposure and an increased risk of obesity. Additionally, a high SUA level was linked to an increased risk of various CVDs. Given that individuals with high SUA are more likely to be susceptible to AF, CAD, and EHT, attention must be given to their weight status.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Úrico
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Biomarcadores
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Doenças Cardiovasculares
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Índice de Massa Corporal
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Predisposição Genética para Doença
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Hiperuricemia
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Estudo de Associação Genômica Ampla
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Análise da Randomização Mendeliana
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Obesidade
Limite:
Female
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Humans
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Male
Idioma:
En
Revista:
Nutr Metab Cardiovasc Dis
Assunto da revista:
ANGIOLOGIA
/
CARDIOLOGIA
/
CIENCIAS DA NUTRICAO
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METABOLISMO
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China