Characterization of an Uncommon Finding in the Basal Nuclei in Beagle Dogs: A Novel Potential Background Lesion in the Canine Brain.
Toxicol Pathol
; 52(5): 295-301, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-39149788
ABSTRACT
Degenerative lesions specific to the basal nuclei have not been described as a background finding in Beagle dogs. This report comprises a documentation of seven cases. In the context of a nonclinical safety studies, the authors suggest documenting the lesion descriptively as degeneration neuropil, basal nuclei, bilateral as it is characterized by (1) vacuolation, neuropil; (2) gliosis (astro- and/or microgliosis); and (3) demyelination. This novel lesion is considered a potential new background change for several reasons (1) It occurred in animals from test item-treated and also vehicle-treated groups; (2) no dose dependency was observed; (3) in one of six affected test item-treated dogs, the given compound was shown not to penetrate the blood-brain barrier; and (4) statistical comparison between the proportions of affected dogs in the treatment and control groups did not yield a statistically significant difference. The etiology remains unknown and is subject to further investigations.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
Limite:
Animals
Idioma:
En
Revista:
Toxicol Pathol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Alemanha