Plasma clearance of intravenously administered pituitary human growth hormone: gel filtration studies of heterogeneous components.
J Clin Endocrinol Metab
; 60(5): 864-7, 1985 May.
Article
em En
| MEDLINE
| ID: mdl-3980671
ABSTRACT
Both pituitary and plasma human GH (hGH) comprise heterogeneous components, exhibiting similar patterns when gel filtered on Sephadex G-100. To determine at what rate the components are cleared from the circulation, blood was obtained at specific intervals following a bolus injection of pituitary hGH in hypopituitary patients. Each sample was gel filtered to determine its component profile of RIA values, which, when plotted vs. the time interval it represented, yielded a means of monitoring its disappearance from the plasma. Total hGH was cleared with a t 1/2 of 21.5 min, the little component was cleared at 19.0 min, the big component was cleared at 26.5 min, and the pre-big component was cleared at 45 min. These data indicate that the larger the hGH component, the longer it takes to be cleared from the plasma.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hormônio do Crescimento
Limite:
Adolescent
/
Adult
/
Humans
Idioma:
En
Revista:
J Clin Endocrinol Metab
Ano de publicação:
1985
Tipo de documento:
Article