Gas-liquid chromatographic measurement of lignocaine in small samples of canine myocardium after enzymatic digestion.
J Clin Pathol
; 32(3): 225-8, 1979 Mar.
Article
em En
| MEDLINE
| ID: mdl-429588
ABSTRACT
A method is described whereby lignocaine can be measured in small samples of canine myocardium. A proteolytic enzyme is used to digest the tissue, and the drug, together with an internal standard, is subsequently extracted into an organic solvent and measured by gas-liquid chromatography. The method is reproducible using tissue samples as small as 50 mg and appears to be suitable for the measurement of a number of drugs in small samples of tissue.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lidocaína
/
Miocárdio
Limite:
Animals
Idioma:
En
Revista:
J Clin Pathol
Ano de publicação:
1979
Tipo de documento:
Article