Thyrotropin secretion in rats after hypothalamic electrical stimulation or injection of synthetic TSH-releasing factor.
Science
; 168(3937): 1366-8, 1970 Jun 12.
Article
em En
| MEDLINE
| ID: mdl-4986307
ABSTRACT
Plasma thyroid-stimulating hormone (TSH) levels, as measured by radioimmunoassay, begin to rise within 5 minutes after initiation of electrical stimulation of the medial-basal hypothalamus, become significantly elevated at 10 minutes, and reach a peak at 10 to 25 minutes. Intravenous administration of synthetic thyrotropin-releasing factor induces a marked rise in plasma thyroidstimulating hormone which is maximal within 5 minutes after administration. These data are interpreted to indicate that there are neuronal structures within the medial-basal hypothalamus which release preformed thyrotropin-releasing factor. The claim (based on bioassay data) that pyroglutamyl-histidyl-proline amide is a potent thyrotropin-releasing factor has also been confirmed by using a highly specific immunoassay system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tireotropina
/
Hormônio Liberador de Tireotropina
/
Estimulação Elétrica
/
Hipotálamo
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1970
Tipo de documento:
Article