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Pancreatic polypeptide update: its roles in detection of the trait for multiple endocrine adenopathy syndrome, type I and pancreatic polypeptide-secreting tumors.
Surgery ; 94(6): 1028-37, 1983 Dec.
Article em En | MEDLINE | ID: mdl-6139885
ABSTRACT
Circulating human pancreatic polypeptide (hPP) concentrations in the plasma of 61 patients were determined by radioimmunoassay and compared with concentrations in normal age-matched subjects to assess the role of plasma hPP in diagnosis and detection of pathologic dysplasias in endocrinopathies. Basal fasting plasma hPP concentrations greater than 3.0 times normal values were found in six of six patients with multiple endocrine adenopathy syndrome, type I (MEA I) who had islet cell tumors that contained hPP and in only three of 15 nonfamilial patients with sporadic islet cell tumors. An exaggerated plasma hPP response to meal stimulation that exceeded greater than 4.5 times the basal value was found in 15 of 18 patients with MEA I, which indicated the presence of endocrine cell hyperplasia as the underlying genetic trait. The abnormal plasma hPP response to meal stimulation correlated most strongly with islet cell hyperplasia in both the genetic and sporadic endocrinopathies and to some extent with antral G cell hyperplasia. In patients with primary hyperparathyroidism, an exaggerated plasma hPP response to meal stimulation is highly indicative of genetic parathyroid hyperplasia in MEA I and not of sporadic parathyroid adenoma. Informed consent was obtained from all patients who were subjects of these investigations.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Neoplasia Endócrina Múltipla / Polipeptídeo Pancreático / Adenoma de Células das Ilhotas Pancreáticas Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Surgery Ano de publicação: 1983 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Neoplasia Endócrina Múltipla / Polipeptídeo Pancreático / Adenoma de Células das Ilhotas Pancreáticas Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Surgery Ano de publicação: 1983 Tipo de documento: Article