p-Aminohippurate (PAH) transport and Na-K-ATPase activity in rat renal cortical slices during postnatal maturation and drug-induced stimulation.
Biochem Pharmacol
; 32(24): 3675-8, 1983 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-6318768
ABSTRACT
PAH transport and Na-K-ATPase activity markedly increase during the first month of postnatal life. Pretreatment of rats with PAH or cyclopenthiazide induces a stimulation of in vitro PAH accumulation in renal cortical slices, whereas Na-K-ATPase activity is unchanged in comparison to saline-pretreated controls. 5 mM ouabain in the incubation medium reduces PAH accumulation. Developmental pattern and stimulation effects are pronounced as in controls. The ouabain-insensitive component of net PAH accumulation progressively increases with age and is significantly enhanced following drug pretreatment, whereas the ouabain-sensitive component of net PAH accumulation shows relatively slight modifications. Consequently, Na-K-ATPase seems not to be linked with postnatal maturation or drug-induced stimulation in tubular PAH transport.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ouabaína
/
Ácido p-Aminoipúrico
/
ATPase Trocadora de Sódio-Potássio
/
Ciclopentiazida
/
Inibidores de Simportadores de Cloreto de Sódio
/
Ácidos Aminoipúricos
/
Córtex Renal
Limite:
Animals
Idioma:
En
Revista:
Biochem Pharmacol
Ano de publicação:
1983
Tipo de documento:
Article