Synthesis of tritium labeled Ac-[Nle4, D-Phe7]-alpha-MSH4-11-NH2: a superpotent melanotropin with prolonged biological activity.
Life Sci
; 34(10): 977-84, 1984 Mar 05.
Article
em En
| MEDLINE
| ID: mdl-6608041
ABSTRACT
Ac-[Nle4, D-Phe7]-alpha-MSH4-11-NH2 an octapeptide, is a melanotropin analogue (Ac-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-NH2), which is a superpotent agonist of frog and lizard skin melanocytes and mouse S 91 (Cloudman) melanoma cells. This melanotropin possesses ultraprolonged activity on melanocytes, both in vitro and in vivo, and the peptide is resistant to inactivation by serum enzymes. The tritium-labeled congener was prepared by direct incorporation of [3H]-labeled norleucine into the peptide. The melanotropic activity of the labeled peptide is identical to the unlabeled analogue. This labeled peptide should be useful for studies on the localization and characterization of melanotropin receptors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alfa-MSH
/
Hormônios Estimuladores de Melanócitos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1984
Tipo de documento:
Article