Murine interstitial nephritis. I. Analysis of disease susceptibility and its relationship of pleiomorphic gene products defining both immune-response genes and a restrictive requirement for cytotoxic T cells at H-2K.
J Exp Med
; 155(4): 1075-85, 1982 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-6801184
ABSTRACT
Anti-tubular basement membrance (alpha TBM) disease-producing interstitial nephritis in mice is not dependent on the generation of alpha TBM antibodies. Susceptibility seems to be defined by very private specificities in H-2K. These specificities are pleiomorphic, providing both immune-response genes and identity restrictions for cytotoxic effector functions expressed by a Thy-1.2+, Lyt-2,3+ T cell. These studies establish a role for T cells in the pathogenesis in interstitial nephritis as well as providing further evidence for the role of H-2K in the expression of an autoimmune disease.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biossíntese de Proteínas
/
Antígenos H-2
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Genes MHC da Classe II
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Nefrite Intersticial
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1982
Tipo de documento:
Article