Digital picture analysis for studying the development of experimentally induced osteosarcoma.
J Cancer Res Clin Oncol
; 104(3): 229-36, 1982.
Article
em En
| MEDLINE
| ID: mdl-6819299
ABSTRACT
We used the method of digital picture analysis to make a quantitative characterization, of stages of development of experimental osteosarcomas in rabbits. DMBA in gelatine pellets placed intraosteally served as a carcinogen to induce bone sarcomas. Of 25 animals treated, eight developed osteosarcomas classified as either osteoblastic, fibroblastic, or chondroblastic. We studied the process of bone neoplasia using radiographic, scintigraphic, and histological methods. To define the progress of neoplastic growth in each tumor we processed sequential radiographs of them by digital picture analysis. For this purpose, we developed a method for quantifying radiological changes using parameters independent of the rotation of the bone. In defining the histologic type of bone sarcomas, besides microscopic features we relied on quantitative criteria such as ratios of the newly formed bone and cartilage to the sarcomatous stroma. Our results, presented in this paper, indicate that digital picture analysis may be useful in characterizing experimental osteosarcomas as a model for therapeutic studies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ósseas
/
Osteossarcoma
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Cancer Res Clin Oncol
Ano de publicação:
1982
Tipo de documento:
Article