The mutagenicity of butadiene towards Salmonella typhimurium.
Toxicol Lett
; 6(3): 125-30, 1980 Aug.
Article
em En
| MEDLINE
| ID: mdl-6996220
ABSTRACT
Gaseous butadiene (BUT) was mutagenic towards S. typhimurium strain TA 1530 when the incubation mixture was supplemented with a NADPH-fortified rat liver microsomal preparation; mutagenicity increased with the dose. A significant mutagenic effect was similarly observed when the petri dishes, containing the bacteria but no metabolic activation system, were incubated in the presence of butadiene, in a desiccator in which plates containing the S-9 rat liver fraction had been placed. This indirect mutagenic effect was attributed to the formation, by the S-9 mix, of volatile intermediate(s) that migrated and induced mutations in neighbouring bacteria.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Salmonella typhimurium
/
Butadienos
/
Mutagênicos
Limite:
Animals
Idioma:
En
Revista:
Toxicol Lett
Ano de publicação:
1980
Tipo de documento:
Article