Promotion of carbohydrate oxidation in the heart by some phenylglyoxylic acids.
J Med Chem
; 24(4): 399-404, 1981 Apr.
Article
em En
| MEDLINE
| ID: mdl-7265127
ABSTRACT
A series of phenylglyoxylic acids is described, many of which are able to promote carbohydrate oxidation in muscle tissue, thereby favorably altering the carbohydrate/fatty acid balance in situations where fatty acid utilization is elevated. Such situations are reported to occur in ischemic heart disease, particularly following myocardial infection. In an attempt to effectively deliver the phenylglyoxylic acids to the site of action within the cell, the L-(+)-phenylglycines were employed as prodrugs. These are known to be transaminated to phenylglyoxylic acids. L-(+)-2-(4-Hydroxyphenyl)glycine (25, oxfenicine) has been selected for clinical evaluation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Metabolismo dos Carboidratos
/
Glioxilatos
/
Miocárdio
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
1981
Tipo de documento:
Article