Effect of indomethacin and naproxen on the metabolism of collagen in adjuvant-induced arthritis.
Scand J Rheumatol
; 10(3): 161-7, 1981.
Article
em En
| MEDLINE
| ID: mdl-7291950
ABSTRACT
The effect of indomethacin and naproxen on collagen metabolism was studied in arthritic animals after an injection of [3H]-proline, both the specific and total radioactivity of [3H]-hydroxyproline being determined in skin collagen fractions and in urine. It was found that collagen synthesis and conversion of soluble to insoluble collagen are diminished, accompanied by an increased collagen degradation in untreated arthritic animals. Administration of indomethacin and naproxen to arthritic animals accelerated the synthesis of collagen and conversion soluble to insoluble collagen and inhibited the catabolism of collagen.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite
/
Artrite Experimental
/
Indometacina
/
Naproxeno
/
Colágeno
Limite:
Animals
Idioma:
En
Revista:
Scand J Rheumatol
Ano de publicação:
1981
Tipo de documento:
Article