Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells.
Nat Med
; 1(12): 1274-8, 1995 Dec.
Article
em En
| MEDLINE
| ID: mdl-7489408
ABSTRACT
Kaposi's sarcoma (KS), a vascular tumour that contains characteristic spindle cells forming slit-like spaces, may have an infectious aetiology. Recently, sequences of a new human herpesvirus, KSHV/HHV-8, have been identified in both HIV-associated and classical KS. We sought to identify the target cell of this virus in KS tumour tissue. Using PCR in situ hybridization (PCR-ISH) we show that KSHV/HHV-8 is present in the flat endothelial cells lining vascular spaces of KS lesions as well as in typical KS spindle cells. These findings show that KSHV/HHV-8 is present in the cell types thought to represent neoplastic cells in these lesions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sarcoma de Kaposi
/
Neoplasias Cutâneas
/
Infecções Oportunistas Relacionadas com a AIDS
/
Nevo Fusocelular
/
Infecções por Herpesviridae
/
Herpesviridae
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Nat Med
Assunto da revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Reino Unido