Possible involvement of tumour cell membrane gangliosides in platelet-tumour cell interactions.
Eur J Cancer
; 31A(1): 79-84, 1995.
Article
em En
| MEDLINE
| ID: mdl-7695984
ABSTRACT
The possible correlation(s) between platelet proaggregating activity, and sialic acid content and ganglioside expression of six human colorectal tumour cell lines (CBS, GEO, HT-29, WiDr, MIP and DLD-1) was evaluated. The three cell lines (HT-29, WiDr and DLD-1) capable of inducing remarkable in vitro platelet aggregation, had significantly higher amounts of lipid-bound sialic acid than those cell lines characterised by a lower platelet proaggregating activity (GEO, CBS and MIP). High performance thin-layer chromatography demonstrated the presence of one band comigrating with GM3 in all cell lines, while GD1a and GT1b comigrating gangliosides were present only in HT-29, WiDr and DLD-1 cells. Finally, an increased platelet pro-aggregating activity of GEO and CBS cell lines was observed after the incorporation of exogenous gangliosides. The present data support the hypothesis that lipid-bound sialic acid may be involved in platelet-tumour cell interactions.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos Siálicos
/
Neoplasias Colorretais
/
Agregação Plaquetária
/
Gangliosídeos
Limite:
Humans
Idioma:
En
Revista:
Eur J Cancer
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Itália