Effect of neopterin and 7,8-dihydroneopterin on tumor necrosis factor-alpha induced programmed cell death.
FEBS Lett
; 364(2): 234-8, 1995 May 08.
Article
em En
| MEDLINE
| ID: mdl-7750578
ABSTRACT
Tumor necrosis factor-alpha and the formation of reactive oxygen intermediates are central mediators of apoptosis. Recent data indicated a role of neopterin and 7,8-dihydroneopterin in oxygen radical mediated processes. We have therefore investigated the effect of neopterin-derivatives on TNF alpha induced apoptosis of the monocyte-like cell line U937. At an elevated concentration 7,8-dihydroneopterin was found to superinduce TNF alpha mediated programmed cell death due to the formation of reactive oxygen intermediates. Our results imply that in combination with TNF alpha high concentrations of 7,8-dihydroneopterin enhances apoptosis due to oxidative stress on cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pteridinas
/
Biopterinas
/
Fator de Necrose Tumoral alfa
/
Apoptose
Limite:
Animals
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Áustria