Bilateral adrenal hemorrhage and adrenal insufficiency in a patient with lymphomatous adrenal infiltration following administration of a fusion toxin (DAB486 interleukin-2).
J Immunother Emphasis Tumor Immunol
; 16(3): 229-33, 1994 Oct.
Article
em En
| MEDLINE
| ID: mdl-7834123
ABSTRACT
DAB486IL-2 is a novel fusion toxin in which the ADP-ribosyltransferase and membrane-translocating domains of diphtheria toxin have been combined with the interleukin-2 (IL-2) gene, creating a recombinant protein capable of selectively intoxicating cells bearing the high-affinity IL-2 receptor. Clinical activity has been documented in Hodgkin disease and the non-Hodgkin lymphomas; toxicities have been minimal and include mild hepatic transaminitis, proteinuria, and hypersensitivity reactions. In this report, a patient with tumor-stage cutaneous T-cell lymphoma developed clinical adrenal failure with bilateral adrenal hemorrhage and necrosis 7 weeks after completing a 5-day course of treatment with DAB486IL-2. The relationship of fusion toxin therapy to the development of this unusual toxicity is discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunotoxinas
/
Interleucina-2
/
Doenças das Glândulas Suprarrenais
/
Toxina Diftérica
/
Hemorragia
Tipo de estudo:
Etiology_studies
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
J Immunother Emphasis Tumor Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
FARMACOLOGIA
/
NEOPLASIAS
Ano de publicação:
1994
Tipo de documento:
Article