[Regressive leukoencephalopathy induced by an overdose of cyclosporine A]. / Leucoencéphalopathie régressive au cours d'un surdosage en cyclosporine A.
Rev Neurol (Paris)
; 149(10): 576-8, 1993.
Article
em Fr
| MEDLINE
| ID: mdl-8023077
ABSTRACT
We report a case of leucoencephalopathy with tremor and generalized motor seizures a few days after introduction of cyclosporin A (Cy A) in a kidney recipient. There was a relationship between acute neurological symptoms and high and sudden blood level of Cy A (1 260 ng/ml; therapeutic range 120-275 ng/ml). White-matter hypodensities at CT scanning and severe slow-waves abnormalities at EEG were present. All neurological symptoms were reversible after Cy A level was lowered. Three months later, a blood Cy A level at 217 ng/ml due to nicardipine co-administration resulted in severe tremor and was reversed by decreasing blood Cy A level to 126 ng/ml.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucoencefalopatia Multifocal Progressiva
/
Ciclosporina
Limite:
Female
/
Humans
/
Middle aged
Idioma:
Fr
Revista:
Rev Neurol (Paris)
Ano de publicação:
1993
Tipo de documento:
Article