Fluoride reversibly blocks HVA calcium current in mammalian thalamic neurones.
Neuroreport
; 5(5): 553-6, 1994 Jan 31.
Article
em En
| MEDLINE
| ID: mdl-8025242
ABSTRACT
The effect of intracellular fluoride ions on voltage-dependent calcium currents was tested during whole-cell voltage-clamp recordings in thalamic neurones acutely dissociated from young adult rats. It is demonstrated that 5-30 mM intracellular fluoride selectively and reversibly suppresses the high voltage-activated, dihydropyridine-sensitive calcium current, without affecting the transient, low voltage-activated calcium current. Intracellular diffusion of a fluoride-free solution restores the blocking effect on the slow inactivating current induced by a transitory fluoride perfusion obtained by filling the patch microelectrode tip with caesium fluoride.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tálamo
/
Canais de Cálcio
/
Cálcio
/
Fluoretos
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Neuroreport
Assunto da revista:
NEUROLOGIA
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Itália