Microtubule-active drugs taxol, vinblastine, and nocodazole increase the levels of transcriptionally active p53.
Cancer Res
; 55(24): 6021-5, 1995 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-8521385
ABSTRACT
A range of DNA-damaging agents has been shown to increase cellular levels of the nuclear phosphoprotein p53 and to induce p53-dependent processes. We examined the ability of three microtubule-active agents, taxol, vinblastine, and nocodazole, to increase p53 levels and activate p53-dependent processes. When tested using a p53 DNA-binding assay, all three agents induced p53 in a dose-dependent manner. To varying degrees, these agents also induced p21WAF1/CIP1 mRNA and transcription in a chloramphenicol acetyl transferase reporter system. These data suggest there is an additional pathway for activating p53 and subsequent p53-dependent processes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Vimblastina
/
Nocodazol
/
Proteína Supressora de Tumor p53
/
Paclitaxel
/
Ciclinas
/
Microtúbulos
Limite:
Animals
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos