Associations of status and change measures of neuropsychological function with pathologic changes in elderly, originally nondemented subjects.
Arch Neurol
; 53(1): 82-7, 1996 Jan.
Article
em En
| MEDLINE
| ID: mdl-8599564
ABSTRACT
OBJECTIVE:
To describe the association between status and change of neuropsychological function and postmortem neuropathologic findings in subjects with Alzheimer's disease, vascular dementia, normal aging, and pathologic aging.DESIGN:
Volunteer cohort study.SETTING:
Volunteers were interviewed and tested in outpatient-clinical research offices.PARTICIPANTS:
Nondemented, healthy, community-residing subjects, initially between 75 and 85 years of age, who participated in the Bronx Aging Study and had at least 2 years of neuropsychological data and quantitative neuropathologic examinations. MAIN OUTCOMEMEASURES:
Initial summary neuropsychological score, rate of change score.RESULTS:
Summary neuropsychological scores at baseline in subjects who subsequently developed pathologically confirmed Alzheimer's disease or vascular dementia were 0.8 z units lower than those of subjects classified in the normal or pathologic aging subgroups (P < .05). Subjects with Alzheimer's disease showed more neuropsychological change over time than subjects in the normal or pathologic aging groups (P < .001). Normal subjects and subjects with pathologic aging did not differ in baseline scores or rate of change. Level of education was strongly associated with initial neuropsychological scores (P < .004), but not with change scores.CONCLUSIONS:
Among elderly, initially nondemented subjects who were followed up until death, subjects with pathologically confirmed Alzheimer's disease or vascular dementia had lower neuropsychological scores at initial evaluation than normal subjects or subjects with pathologic aging. Subjects with Alzheimer's disease had a more rapid rate of decline than normal subjects or subjects with pathologic aging.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Demência Vascular
/
Nível de Saúde
/
Saúde Mental
/
Doença de Alzheimer
Tipo de estudo:
Observational_studies
/
Qualitative_research
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Humans
Idioma:
En
Revista:
Arch Neurol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos