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Brief dietary restriction increases skeletal muscle glucose transport in old Fischer 344 rats.
Dean, D J; Cartee, G D.
Afiliação
  • Dean DJ; Biodynamics Laboratory, University of Wisconsin, Madison, USA.
J Gerontol A Biol Sci Med Sci ; 51(3): B208-13, 1996 May.
Article em En | MEDLINE | ID: mdl-8630697
The primary purpose of this study was to determine the impact of brief dietary restriction (DR; 5 or 20 days) on skeletal muscle glucose transport activity (GTA) of 24-month-old female Fischer 344 rats. Basal GTA of isolated epitrochlearis muscles was unaffected by DR. Insulin-stimulated GTA was significantly increased by DR only at 20 days (51%). We also assessed the influence of DR on energy sources (blood-borne and stored). An approximately 20% decline in glycemia occurred in each DR group, but plasma-free fatty acid and beta-hydroxybutyrate concentrations were unaffected. Plasma insulin was reduced by 50% after 20 days. Hepatic glycogen was rapidly mobilized (-69% at 5 days; -83% at 20 days). The depletions of visceral adipose stores was slower (no significant decline at 5 days; -30% at 20 days), but the eventual reduction accounts for a significant amount of energy. The results demonstrate that muscle from old rats can rapidly upregulate GTA in response to brief DR. The relative magnitude of this increase represents a substantial portion of the increases previously observed after prolonged DR.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Músculo Esquelético / Dieta / Glucose Limite: Animals Idioma: En Revista: J Gerontol A Biol Sci Med Sci Assunto da revista: GERIATRIA Ano de publicação: 1996 Tipo de documento: Article País de afiliação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Músculo Esquelético / Dieta / Glucose Limite: Animals Idioma: En Revista: J Gerontol A Biol Sci Med Sci Assunto da revista: GERIATRIA Ano de publicação: 1996 Tipo de documento: Article País de afiliação: Estados Unidos