Vitamin E protects against bacterial endotoxin-induced increase of plasma corticosterone and brain glutamate in the rat.
Res Commun Mol Pathol Pharmacol
; 92(1): 95-105, 1996 Apr.
Article
em En
| MEDLINE
| ID: mdl-8733831
ABSTRACT
Plasma corticosterone (CS) and brain free aminoacids were determined in male rats 2 hr after acute exposure to bacterial endotoxin stress BES (2.0 mg/kg i.p. of lipopolysaccharide, LPS). A significant increase in the levels of plasma CS and brain taurine (Tau), aspartate (As), glutamate (Glu), glycine (Gly) and valine (Val) was observed following BES. When vitamin E (alpha-tocopherol acetate AT) was given orally (0.25 gm/kg/day) 4 days before induction of BES, the plasma CS as well as the brain Glu levels were significantly reduced to the control values. These results indicate that plasma CS and brain Glu may be involved in the mechanisms by which AT protects against the neurotoxicity of BES.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitamina E
/
Encéfalo
/
Corticosterona
/
Ácido Glutâmico
/
Endotoxinas
Limite:
Animals
Idioma:
En
Revista:
Res Commun Mol Pathol Pharmacol
Assunto da revista:
BIOLOGIA MOLECULAR
/
FARMACOLOGIA
/
PATOLOGIA
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Arábia Saudita