Potential of T2 relaxation time measurements for early detection of radiation injury to the brain: experimental study in pigs.
AJNR Am J Neuroradiol
; 17(5): 907-12, 1996 May.
Article
em En
| MEDLINE
| ID: mdl-8733966
ABSTRACT
PURPOSE:
To investigate the MR T2 relaxation time and histologic changes after a single-fraction 25-Gy dose of radiation to the brain of pigs.METHODS:
The right hemisphere of 10 Meishan pigs was irradiated with a single dose of 25 GY at the 90% isodose, using a 12-MeV electron beam. T2 relaxation time was measured within three regions of interest in the brain those that had received 90%, 70%, and 40% of the total dose, respectively. T2 kinetics over time was compared with histologic studies.RESULTS:
Brain T2 values were noted to increase within the irradiated areas. T2 kinetics were analyzed in three phases an immediate transient phase and two long-lasting phases. These two long-lasting phases were correlated with the detection of ventricular compression and necrosis, respectively. The T2 increase within the 90% region of interest was 19%, 22%, and 26% for phases I, II, and III, respectively. T2 measurements within other regions of interest were not significant.CONCLUSION:
Although our results suggest a dose threshold for T2 variations, brain T2 values increased after irradiation at a level at which disease could not be seen on conventional MR images. This illustrates the value of using conventional MR imaging in a quantitative manner to assess molecular tissue abnormalities at earlier stages of developing diseases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lesões Experimentais por Radiação
/
Encéfalo
/
Encefalopatias
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Imageamento por Ressonância Magnética
Tipo de estudo:
Diagnostic_studies
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Screening_studies
Limite:
Animals
Idioma:
En
Revista:
AJNR Am J Neuroradiol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
França