Parallel-compound synthesis: methodology for accelerating drug discovery.
Bioorg Med Chem
; 4(5): 645-54, 1996 May.
Article
em En
| MEDLINE
| ID: mdl-8804528
ABSTRACT
Parallel compound synthesis enables large numbers of individual compounds to be prepared simultaneously using semiautomated techniques. This fast and efficient methodology has an important role to play in accelerating lead optimisation and hence the whole drug discovery process. The potential of this strategy to rapidly optimise chemical leads and provide structure-activity relationship (SAR) information was demonstrated in two therapeutic areas, antiviral agents (herpes simplex virus), and neurokinin-2 receptor antagonists.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Preparações Farmacêuticas
/
Desenho de Fármacos
/
Receptores da Neurocinina-2
/
Herpesvirus Humano 1
/
Avaliação Pré-Clínica de Medicamentos
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Reino Unido