Topical corticosteroid treatment of anosmia associated with nasal and sinus disease.
Arch Otolaryngol Head Neck Surg
; 123(4): 367-72, 1997 Apr.
Article
em En
| MEDLINE
| ID: mdl-9109781
ABSTRACT
OBJECTIVE:
To establish the efficacy of topical corticosteroid nasal spray treatment of severe olfactory loss associated with severe nasal and sinus disease.DESIGN:
Efficacy before and after open-label trial of topical corticosteroid nasal spray used exclusively in the head-down-forward position.SETTING:
Taste and smell clinic of a university teaching hospital and research facility. PATIENTS Taste and smell clinic patients with anosmia or severe hyposmia associated with paranasal sinus disease and nasal polyposis including 39 of 45 patients recruited from 1988 to 1994 who completed the topical corticosteroid treatment course and returned for subsequent testing. INTERVENTION At least 8 weeks of treatment with flunisolide (Nasalide), 2 sprays in each nostril twice a day, with concurrent antibiotic treatment of any bacterial infection. MAIN OUTCOMEMEASURES:
Subjective olfactory symptoms, objective olfactory function tests, and otolaryngological evaluation (including endoscopic examination).RESULTS:
Olfactory scores significantly improved following treatment (P < .001); signs of nasal and sinus disease significantly decreased (P < .001); and 26 (66%) of the patients reported a subjective improvement in their sense of smell.CONCLUSION:
Topical corticosteroid nasal spray administered in a head-down-forward position is an effective treatment of severe olfactory loss associated with severe nasal and sinus disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças dos Seios Paranasais
/
Fluocinolona Acetonida
/
Pólipos Nasais
/
Transtornos do Olfato
/
Anti-Inflamatórios
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Arch Otolaryngol Head Neck Surg
Assunto da revista:
OTORRINOLARINGOLOGIA
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos