Comparison of iodinated contrast media-induced renal vasoconstriction in human, rabbit, dog, and pig arteries.
Invest Radiol
; 32(6): 315-9, 1997 Jun.
Article
em En
| MEDLINE
| ID: mdl-9179705
ABSTRACT
RATIONALE AND OBJECTIVES:
Contrast media (CM)-induced renal vasoconstriction is an important factor in the pathogenesis of CM-induced nephrotoxicity. The effects of ionic, high-osmolar CM sodium/meglumine diatrizoate and nonionic, low-osmolar CM iohexol and iopamidol were studied in rabbit, dog, and pig renal arteries and compared with human tissue in an organ bath.METHODS:
Isometric contractions were induced by increasing concentrations of CM and high-osmolar glucose solution.RESULTS:
Contrast media and glucose elicited contractions in human renal arteries of 32% (diatrizoate), 20% (iohexol), 30% (iopamidol), and 22% (glucose). Rabbit and dog renal arteries demonstrated contractions of 30% and 46% (diatrizoate), 15% and 23% (iohexol), 15% and 26% (iopamidol), and 11% and 40% (glucose), respectively, of the control. There was a vasorelaxing effect of all CM tested on pig renal artery.CONCLUSIONS:
Responses in rabbit and dog renal arteries were similar to those in human renal arteries and could serve as models for investigating CM-induced renal vasoconstriction.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artéria Renal
/
Vasoconstrição
/
Meios de Contraste
/
Músculo Liso Vascular
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Invest Radiol
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos