Binding of neuroligins to PSD-95.
Science
; 277(5331): 1511-5, 1997 Sep 05.
Article
em En
| MEDLINE
| ID: mdl-9278515
ABSTRACT
PSD-95 is a component of postsynaptic densities in central synapses. It contains three PDZ domains that localize N-methyl-D-aspartate receptor subunit 2 (NMDA2 receptor) and K+ channels to synapses. In mouse forebrain, PSD-95 bound to the cytoplasmic COOH-termini of neuroligins, which are neuronal cell adhesion molecules that interact with beta-neurexins and form intercellular junctions. Neuroligins bind to the third PDZ domain of PSD-95, whereas NMDA2 receptors and K+ channels interact with the first and second PDZ domains. Thus different PDZ domains of PSD-95 are specialized for distinct functions. PSD-95 may recruit ion channels and neurotransmitter receptors to intercellular junctions formed between neurons by neuroligins and beta-neurexins.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prosencéfalo
/
Proteínas Quinases Dependentes de Cálcio-Calmodulina
/
Proteínas de Membrana
/
Proteínas do Tecido Nervoso
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Japão