Human cDNA encoding a novel TGF-beta superfamily protein highly expressed in placenta.
J Biochem
; 122(3): 622-6, 1997 Sep.
Article
em En
| MEDLINE
| ID: mdl-9348093
ABSTRACT
Recently, we developed a simple method for detecting a secretory signal sequence encoded by a cDNA fragment. In this study, we used this method to select cDNA clones encoding secretory proteins from a human full-length cDNA library. Full-sequencing analysis of the candidate clones revealed that one clone encoded a novel TGF-beta superfamily protein. The clone encodes a protein of 308 amino acids of which the C-terminal region shows a characteristic feature of TGF-beta superfamily proteins seven conserved cysteine residues at the C-terminal preceded by a putative processing site composed of a basic amino acid repeat. The corresponding transcripts are highly expressed in the placenta, so the novel protein may play an important role in reproduction.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Transformador beta
/
DNA Complementar
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Biochem
Ano de publicação:
1997
Tipo de documento:
Article