Trojan peptides: the penetratin system for intracellular delivery.
Trends Cell Biol
; 8(2): 84-7, 1998 Feb.
Article
em En
| MEDLINE
| ID: mdl-9695814
ABSTRACT
Internalization of exogenous macromolecules by live cells provides a powerful approach for studying cellular functions. Understanding the mechanism of transfer from the extracellular milieu to the cytoplasm and nucleus could also contribute to the development of new therapeutic approaches. This article summarizes the unexpected properties of penetratins, a class of peptides with translocating properties and capable of carrying hydrophilic compounds across the plasma membrane. This unique system allows direct targeting of oligopeptides and oligonucleotides to the cytoplasm and nucleus, is non-cell-type specific and highly efficient, and therefore has several applications of potential cell-biology and clinical interest.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Núcleo Celular
/
Proteínas de Homeodomínio
/
Citoplasma
Limite:
Animals
Idioma:
En
Revista:
Trends Cell Biol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Reino Unido