Clinical application of the measurement of spontaneous erythrocyte aggregation and disaggregation. A pilot study.
Clin Hemorheol Microcirc
; 18(2-3): 87-97, 1998 Jul.
Article
em En
| MEDLINE
| ID: mdl-9699029
ABSTRACT
Aggregation and disaggregation kinetics of erythrocytes in samples of whole blood were studied using a backscattering nephelometry technique. Blood was drawn from normal subjects and from patients suffering from different diseases chronic glomerulonephritis, systemic lupus erythematosus, hereditary hypercholesterolemia, pulmonary hypertension, intestinal tumors preoperatively (age > 60 years), psoriasis, psoriatic arthritis, ischemia and ischemia with diabetes. Blood samples of healthy donors were used as controls. The backscattering signal in the erythroaggregometer was processed according to algorithms yielding quantitative data on the full amplitude of aggregation, characteristic times of spontaneous aggregation, average hydrodynamic strength of all aggregates and, whenever possible, additionally, strength of the largest aggregates. The obtained results confirm that the complexity of erythrocyte aggregation kinetics requires multiparametric description which, when applied to clinical material, enables the differentiation of aggregation characteristics between diseases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Agregação Eritrocítica
Limite:
Humans
Idioma:
En
Revista:
Clin Hemorheol Microcirc
Assunto da revista:
ANGIOLOGIA
/
HEMATOLOGIA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Federação Russa